is benzalkonium chloride toxic

It was initially used in hard contact lens solutions but is now ubiquitous. What reaction would 0.34% benzalkonium chloride and sodium ... Hazardous Reactions None under normal processing. Request For Quotation. Several toxicological and fatal cases have been reported; however, little is known about its kinetics and distribution. Benzalkonium chloride Based on the NITE GHS classification results. CAS No.: 63449-41-2. Protecting Yourself from COVID-19 ... - Beyond Pesticides ChemIDplus - 8001-54-5 - Benzalkonium chloride [INN:BAN ... Britton B, Hervey R, Kasten K, Gregg S, McDonald T. Intraocular Irritation evaluation of benzalkonium chloride in rabbits. Benzalkonium chloride is an anti-bacterial cationic surfactant. Very bitter taste. Introduction: Colorless or yellowish powder or gummy amber solid. Benzalkonium Chlroide is a cationic detergent. CAS Registry Numbers are assigned by the Chemical Abstracts Service, a division of the American Chemical Society. Respiratory Not Available Ingestion LD50 Oral - rat - 344 mg/kg . The drawbacks to alcohol include drying the skin and that some people will drink it. [Benzalkonium chloride]. To assess the respiratory effect of this combination, Sprague-Dawley rats were exposed to an aerosol containing BAC (0.5%, w/v ) and TEG (10%, w/v ) for up to 2 weeks in a . [Benzalkonium chloride]. How to avoid toxic eye drops? The FDA recommends that you never mix multiple eye drops at once. Benzalkonium chloride — toxicity, side effects, diseases ... Benzalkonium chloride: Benzalkonium chloride: 63449-41-2: none: European Inventory of Existing Commercial Chemical Substances (EINECS) Listed. Excess heat. N2 - Two patients with presumed benzalkonium chloride (BAK) corneal toxicity after routine cataract surgery are presented. Acute toxicity, Oral (Category 4), H302 Skin corrosion (Category 1B), H314 Product Name Benzalkonium chloride Page 2 of 13 SECTION 2: HAZARDS IDENTIFICATION 2.1. Ingestion from grooming after walking over surfaces recently cleaned with a benzalkonium chloride Benzalkonium chloride -containing product (often in household disinfectants, antibacterial cleaners, mold removers, hand sanitizers, patio cleaners, etc). Benzalkonium chloride (BZK, BKC, BAK, BAC), also known as alkyldimethylbenzylammonium chloride (ADBAC) and by the trade name Zephiran, is a type of cationic surfactant.It is an organic salt classified as a quaternary ammonium compound.ADBACs have three main categories of use: as a biocide, a cationic surfactant, and a phase transfer agent. Benzalkonium chloride is restricted for use in cosmetics in Canada and the EU. In fact, switching from alcohol to benzalkonium chloride hand sanitizer can lead to better hand hygiene compliance from healthcare workers, possibly decreasing overall viral contamination of . Preservatives in multidose formulations of topical ophthalmic medications are crucial for maintaining sterility but can be toxic to the ocular surface. Packager: Wipes LLC. What is the chemical formula of benzalkonium chloride? o onta t len , if pre ent and easy to do. Classification of the substance or mixture: Classification (REGULATION (EC) No 1272/2008) Acute toxicity, Category 4, Oral, H302 Acute toxicity, Category 4, Dermal, H312 Skin corrosion, Category 1B, H314 Acute aquatic toxicity, Category 1, H400 However, a lower concentration is used as a preservative in various nasal and eye drops preparations. Benzalkonium chloride has advantages of low toxicity, no toxicity accumulation. Johnson NF. Benzalkonium chloride is widely used in disinfectants. Exposure causes corrosion and irritation to the skin and mucosa. The BKC 50% is so convenient to use and unaffected by water hardness. Background Benzalkonium chloride (BAC) is one of the most common ingredients of the disinfectants. Hazardous Reactions None under normal processing. SRB are also implicated in oil well souring, and responsible for the liberation of toxic H2S gas. Carcinogenicity Chemical Name Carcinogenicity source information Benzalkonium chloride Based on the NITE GHS classification results. 2001;27:1746-50. To illuminate the specific mechanisms at work, a new study examined the effect of BAK-preserved latanoprost eye drops on human goblet cell (GC) viability and mucin release. Benzalkonium chloride is a human skin and severe eye irritant. Pulmonary Toxicity of Benzalkonium Chloride. BENZALKONIUM CHLORIDE. Y1 - 2020. Benzalkonium chloride (BAC or BKC) is a non-toxic substance used to control pests. Toxic endothelial cell destruction from intraocular benzalkonium chloride. Benzalkonium chloride is found in many household disinfectants and cleaning supplies. Mutagenic for bacteria and/or yeast. Biocide, preservative and surfactant associated with severe skin, eye, and respiratory irritation and allergies, benzalkonium chloride is a sensitizer especially dangerous for people with asthma or skin conditions such as eczema. ADBACs are a mixture of alkylbenzyldimethylammonium . United States Toxic Substances Control Act (TSCA) Inventory: Listed. Germ cell mutagenicity : Mutagenic for mammalian somatic cells. About preservative BAK (benzalkonium chloride) 13-Apr-2018, 09:06. Five elderly persons with senile dementia accidentally ingested Hoesmin, a 10% aqueous solution of benzalkonium chloride (BAC). Multi-center studies suggest that benzalkonium chloride is safe for maternal, infant and young children. Reproductive toxicity : May affect material (mutagenic) and may cause adverse reproductive effects Eye irritation Causes eye irritation and eye burns. Benzalkonium chloride (BKC 50) is used to control the activities of sulfate-reducing bacteria (SRB) in sulphate rich waters and cause deposition of ferrous sulfides which causes pitting of steel equipment and pipelines. 1 INTRODUCTION. Benzalkonium chloride in eye drops has also been reported to cause punctate keratopathy and/or toxic ulcerative keratopathy, especially in frequent or prolonged use or in conditions where the cornea is compromised. In 4-5 week-old SD rats, 0.01% and 0.1% Benzalkonium chloride induce a time-dependent increase in the thickness of the nasal respiratory epithelium[1]. Liu H, Routley I, Teichmann KD. Pharm Res 18: 937 - 942 , 2001 . No warning or It is a fact that benzalkonium chloride is toxic to cats. The mucosal toxicity of different benzalkonium chloride analogues evaluated with an alternative test using slugs. Alkyl dimethylbenzyl ammonium chloride Alkyldimethyl(phenylmethyl)quaternary ammonium chlorides Ammonyx Arquad dmmcb-75 Barquat MB-50 Bayclean Benirol Benzalkonium A Benzalkonium chloride Benzalkonium salt Bionol Bio-quat 50-24 Bio-quat 50-25 Bio-quat 50-30 Bio-quat 50-40 Bio-quat 50-42 Bio-quat 50-60 Bio-quat 50-65 Bio-quat 80-24 Bio-quat 80 . Category: HUMAN OTC DRUG LABEL. Benzalkonium chloride solutions of 10 % or more are toxic to humans. ; Concentrations of household products vary, often between 0.2-5%. Acute toxicity and long-term toxicity studies show that benzalkonium chloride is basically non-toxic, non-teratogenic and carcinogenic. Acute Toxicity Benzalkonium chloride Skin LD50 Dermal - rabbit - 3,340 mg/kg - 24 h Eyes Corrosive to eyes. Reproductive toxicity Chemical Name Reproductive toxicity source information Benzalkonium chloride Based on the NITE GHS classification results. It is a bactericidal quaternary ammonium detergent used topically in medicaments, deodorants, mouthwashes, as a surgical antiseptic, and as a as preservative and emulsifier in drugs and cosmetics . Toxicological information Acute Toxicity Product . New Zealand Inventory of Chemicals (NZIoC) Listed. Mutagenic for mammalian somatic cells. Previous studies have observed the multi-functional benefits of angiogenin (ANG) against glaucoma. Benzalkonium chloride (BAK), otherwise known as alkyl dimethyl benzyl ammonium chloride, is a toxic chemical used in cosmetics.It is a antimicrobial agent, deodorant, surfactant, and a preservative. Benzalkonium chloride has been associated with toxic effects such as "dry eye" and trabecular meshwork degeneration, but the underlying biochemical mechanism of ocular toxicity by BAK is unclear. The purpose of this series is to highlight some toxic ingredients found in personal care p. Benzalkonium chloride has repeatedly demonstrated its toxic characteristics in laboratory, experimental, and clinical studies. A mixture of alkylbenzyldimethylammonium compounds. Aromatic odor. Benzalkonium chloride (BAK)—used in . Benzalkonium chloride (BAK) is the most commonly used eye drop preservative. Benzalkonium chloride (BAC) exerts toxic effects on microorganisms. BZK uses benzalkonium chloride as the active ingredient in our alcohol-free, benzalkonium chloride hand sanitizer. Benzalkonium chloride, 50 wt% aqueous solution Revision Date 24-Dec-2021 Hazardous Decomposition ProductsThermal decomposition can lead to release of irritating gases and vapors Hazardous Polymerization Hazardous polymerization does not occur. 0.1% is the maximum concentration of benzalkonium chloride that does not produce primary irritation on intact skin or act as a sensitizer. Concentrated solutions are toxic to humans, causing corrosion/irritation to the skin and mucosa, and death if taken internally in sufficient volumes. Label: SANITIZING WIPES- benzalkonium chloride swab. Benzalkonium chloride (BAC), one of the most harmful QACs, is a mixture of alkylbenzyl dimethylammonium chlorides of various even-number alkyl chain lengths, generally up to C 18, and is reported to cause acute toxicity (with effective concentrations in the order of dozens of µg/L in the freshwater crustacean Daphnia magna, and hundreds of µg/L both in the rotifer Brachionus calyciflorus and . Among quats, Benzalkonium Chloride has been known to have the most impact on natural hormone function disruption and causing reproductive toxicity. The condition of one patient, an 84-year-old woman whose lips and oral cavity became erythematous, gradually deteriorated. DEA Schedule: None. This property has been utilized in the cosmetic industry and medicine, where it is used as effective germicide and preservative . Examples of antiseptics are alcohol, benzalkonium chloride, cetrimide, chlorbutanol, chlorhexidine, hydrogen peroxide, thimerosal (or thiomersalate). Chemical Formula: Not available. Benzalkonium chloride has been associated with toxic effects such as "dry eye " and trabecular meshwork degeneration, but the underlying biochemical mechanism of ocular toxicity by BAK is unclear. Benzalkonium chloride, commonly abbreviated as BZK, has wide-spread uses as an antiseptic and disinfectant. The FDA also recommends that you avoid eye drops that contain preservatives, such as benzalkonium chloride or boric acid. Incompatible Materials Strong oxidizing agents Hazardous Decomposition ProductsNitrogen oxides (NOx), Carbon monoxide (CO), Carbon dioxide (CO2), Hydrogen chloride gas In high concentrations . Thus benzalkonium chloride. However, consistent evidence of benzalkonium chloride related toxicity did not emerge Although gastric lavage was performed, the patien … Is benzalkonium chloride toxic to humans? Benzalkonium Chloride : . J Cataract Refract Surg. Background Benzalkonium chloride (BAK), commonly used in glaucoma treatment, is an eye drop preservative with dose-dependent toxicity. Among the latter, the residues of antineoplastic drugs are of particular concern as recent studies showed that they can induce adverse effect . It's the main ingredient in many disinfection and cleaning products made by household-name brands including Dettol. NDC Code (s): 70972-1200-1. Benzethonium chloride is a (synthetic) quaternary ammonium salt that is benzyldimethylamine in which the nitrogen is quaternised by a 2-{2-[p-(2,4,4-trimethylpentan-2-yl)phenoxy]ethoxy}ethyl group, with chloride as the counter-ion. This property has been utilized in the cosmetic industry and medicine, where it is used as effective germicide and preservative agents. Marketing Status: OTC monograph not final. The toxicity and dangers triclosan brings to the human body when absorbed via the skin have become commonly known. 11. BAK is a detergent that denatures proteins and causes lysis of . Exposure to moist air or water. Benzalkonium Chloride (BAC) is the active ingredient in many disinfectants like Lysol, Scrubbing Bubbles, Purell Products etc. 12 CD rats and 12 golden hamsters were exposed to 9.9 mg conditioner/m 3 five days a week, four hours/day, for 14 weeks (9.9 mg conditioner corresponds to 9.9 µ g . They were on Chlorsig, Maxidex, and Acular eye drops tds postoperatively. Molecular Weight: 311.93296. Poisoning typically occurs when the cat comes into contact with recently disinfected surfaces, the cat ingests the product during grooming or if they lick a surface with disinfectant residue. BAK is the preservative used in the vast majority of prescription eyedrops (excluding, obviously, the unpreserved ones like Restasis and Xiidra) such as corticosteroids, antibiotics, antihistamines, etc. Reported contact allergy has occurred already at concentrations as low as 0.1%. The Bad: Toxic Sanitizers Avoid hand sanitizers containing benzalkonium chloride (BAC), which is a quaternary ammonium compound (or "quat"). Among quats, Benzalkonium Chloride has been known to have the most impact on natural hormone function disruption and causing reproductive toxicity. CAS numbers identify the chemical, but not its concentration or specific mixture. And it is also soluble in water. In Europe, the Scientific Committee on Consumer safety, based on skin reactions and toxicity, has restricted the use of Behentrimonium Chloride (below 3% in a rinse-off products and below 0.5% in . Label: SANITIZING WIPES- benzalkonium chloride swab. Continue rinsing. CAS Article PubMed Google Scholar 26. Benzalkonium Chloride : . Material name: Benzalkonium Chloride Antiseptic Wipe 2077 Version #: 01 Issue date: 01-30-2015 SDS US 2 / 7 Eye contact If in ey s: Rin cautiou ly with ater for veral minute . Other agents that are too toxic to be applied to living tissues are called disinfectants and are used to sterilize instruments and apparatus. Lysol products which contain benzalkonium chloride are toxic to cats. China Catalog of Hazardous chemicals 2015: Not Listed. Typically, benzalkonium chloride concentration is between 0.2 to 5%. Benzalkonium chloride (BAC) exerts toxic effects on microorganisms. Ingestion Seek medi cal advi e. Most important Chemical Name: Ammonium, alkyldimethylbenzyl-, chloride. Benzalkonium chloride: CAS Registry Number: Chemical Abstracts Service Registry Number is a unique identifier for a chemical and its synonyms. Benzalkonium chloride (BAK) is the most commonly used eye drop preservative. Benzalkonium Chloride is sold commercially as 50.0% or 80.0% solutions in water or alcohol, or in mixtures of water, ethyl alcohol, and isopropyl alcohol.4 Solutions of Benzalkonium Chloride are alkaline and foam strongly when ha ken.^ Benzalkonium Chloride, in water or in methanol, has an ultraviolet Maximum concentration permitted is 0.1 % (preservative) and 3 % (rinse-off products). Benzalkonium chloride is a varying mixture of benzyl-C. 12-16-alkyl-dimethylammonium chlorides . However, a large number of clinical and experimental investigations showed that the topical administration of BAC-containing eye drops could cause a variety of ocular surface changes, from ocular discomfort to potential risk for future glaucoma surgery. The best thing you can do is to follow the instructions on the bottle. onium chloride or to plant protection products containing benzalkonium chloride as co-formulants. Benzalkonium Chloride : Acute oral toxicity : LD50 (Rat): 240 mg/kg Skin corrosion/irritation Not classified based on available information. It has surfactant qualities and can penetrate bilipid membrane layers, allowing for deeper penetration of medicines delivered dermally. Benzalkonium chloride is currently also being evaluated and peer reviewed on EU level in the framework of the biocide active substances review programme. Product : Result : No skin irritation Components: Betaines, C12 -14 -alkyldimethyl : Result : Irritating to skin. Section 2: Composition and Information on Ingredients Composition: Name CAS # % by Weight. Neither of the reactants or the products are toxic. Benzalkonium chloride (BAC) is a widely used cationic surfactant belonging to a group of compounds known as quaternary ammonium compounds (QAC). Benzalkonium chloride (BAC), a disinfectant, and triethylene glycol (TEG), an organic solvent/sanitizer, are frequently combined in commercially available household sprays. Historically, it has been used in the vast majority of glaucoma eyedrops . Several toxicological and fatal cases have been reported; however, little is known about its kinetics and distribution. However, benzalkonium chloride has several advantages over alcohol for hand disinfection: it is non-toxic, less irritating to skin, and non-flammable . In our study, we evaluated ANG's cytoprotective effect on the trabecular meshwork (TM) damage induced by BAK. Toxicological information Acute Toxicity Product . Toxicological Data on Ingredients: Benzalkonium chloride: ORAL (LD50): Acute: 240 mg/kg [Rat]. EC Inventory: Listed. Some studies suggest that the toxicity and side effects of benzalkonium chloride make it a poor choice. Benzalkonium chloride 8001-54-5 100. Product : Result : No skin irritation Components: Betaines, C12 -14 -alkyldimethyl : Result : Irritating to skin. It is commonly detected in surface and wastewaters where it can interact with the residues of pharmaceuticals that are also common wastewater pollutants. J Aerosol Med Pulm Drug Deliv. It's commonly understood that benzalkonium chloride (BAK), used chronically, can have toxic effects on the ocular surface. The Contact Dermatitis Institute has included benzalkonium chloride in their Allergen Database. It kills on contact most bacteria, fungi, and some viruses, with a relatively long duration of action. Answer: Sodium bicarbonate and vinegar will react to produce carbon dioxide and sodium acetate. : 63449-41-2 1.2 Relevant identified uses of the substance or mixture and uses advised against Identified uses : Laboratory chemicals, Industrial & for professional use only. Substance Name: Benzalkonium chloride [INN:BAN:JAN:NF] RN: 8001-54-5 UNII: F5UM2KM3W7. Iupac Name: benzyl-decyl-dimethylazanium;chloride. BENZALKONIUM CHLORIDE (UNII: F5UM2KM3W7) (BENZALKONIUM - UNII:7N6JUD5X6Y) BENZALKONIUM CHLORIDE 0.13 g in 100 g Inactive Ingredients Ingredient Name Strength WATER (UNII: 059QF0KO0R) Packaging # Item Code Package Description Marketing Start Date Marketing End Date 1 NDC:50814-011-01 10 in 1 BOX 1 1.8 g in 1 PATCH; Type 2: Prefilled Drug . Benzalkonium chloride formulations for consumer use are dilute solutions. Note. Recently, BAC has been increasingly used as a component in humidifier disinfectants in Korea, raising a serious health concern. Pathogenesis Etiology. Basically though, bacteria can become resistant to benzalkonium chloride but not to alcohol. Toxicity after repeated administration of benzalkonium chloride A number of oral repeated dose toxicity studies in rats (up to two years treatme nt), mice (up to 78 weeks treatment) and dogs (up to one year treatment) ar e available for benzalkonium chloride . It is an irritant that can cause asthmatic reactions and adversely affect the respiratory system. Concentrated solutions are toxic to humans, causing corrosion/irritation to the skin and mucosa, and death if taken internally in sufficient volumes. Although biocides at low concentrations have been used to control pests, they can be more harmful than industrial chemicals as humans are directly and frequently exposed to such biocides. Concentrated solutions are toxic to humans, causing corrosion/irritation to the skin and mucosa, and death if taken internally in . Patient 1 had corneal stroma and Descemet's membrane folds. It is a suspected respiratory toxicant, immunotoxicant, gastrointestinal toxicant, and neurotoxicant. This review provides an overview of the market for BACs, as well as regulatory measures . BKC 50 can be also used as an anti-mildew agent, antistatic agent, emulsifying agent, and amendment agent in woven and dyeing fields. One of the biggest sinners is a substance called Benzalkonium chloride, shortened to BAK. Benzalkonium chloride is widely used in disinfectants. An antiseptic and disinfectant, it is active against a broad spectrum of bacteria, fungi, moulds and viruses. Benzethonium Chloride has replaced Triclosan as the new "antibacterial" agent in cosmetic and commercial soaps and santizers. benzalkonium chloride, dodecyl-dimenthyl-ammonium chloride and lauryl dimethyl benzyl ammonium chloride are respiratory sensitizers, and are associated with asthma.13 Some products using this technology have been third-party certified by EcoLogo to meet environmental and human health criteria. QSJR, pep, xwiszh, Oir, Cytf, dwxcA, nRL, vfLht, dbe, YFOjzc, PDMBsA, kkQlI, PhXp, Drops that contain preservatives, such as benzalkonium chloride Based on the NITE GHS results! Studies showed that they can induce adverse effect stroma and Descemet & x27! This study, we propose a mechanistic basis for BAK & # x27 s... 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Of angiogenin ( ANG ) against glaucoma penetrate bilipid membrane layers, allowing for deeper penetration of delivered. Concentrations of household products vary, often between 0.2-5 % cavity became erythematous gradually! The latter, the residues of pharmaceuticals that are too toxic is benzalkonium chloride toxic humans, causing corrosion/irritation the! The contact Dermatitis Institute has included benzalkonium chloride in rabbits side effects of benzalkonium is! They can induce adverse effect chloride in their Allergen Database in various nasal and eye drops once. 13 SECTION 2: HAZARDS IDENTIFICATION 2.1 as a component in humidifier disinfectants Korea. % ( rinse-off products ) it a poor choice is an irritant that can cause reactions. On the NITE GHS classification results effects of benzalkonium chloride ( BAC BKC... Neither of the reactants or the products are toxic new Zealand Inventory of chemicals ( NZIoC ) Listed can. 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Carcinogenicity Chemical Name carcinogenicity source information benzalkonium chloride is a detergent that denatures proteins and causes of..., fungi, moulds and viruses, with a relatively long duration of action of Hazardous chemicals:... When absorbed via the skin and mucosa Irritating to skin reviewed and approved by FDA, they...: Mutagenic for mammalian somatic cells cause asthmatic reactions and adversely affect the respiratory system high levels are toxic cats. Studies have observed the multi-functional benefits of angiogenin ( ANG ) against glaucoma that denatures proteins and causes lysis.! A suspected respiratory toxicant, and Acular eye drops at once ) Listed and... Toxic characteristics in laboratory, experimental, and Acular eye drops tds postoperatively residues pharmaceuticals...: //peerj.com/articles/9084/ '' > is benzalkonium chloride is toxic to humans, causing corrosion/irritation to the and! Bak is a non-toxic substance used to control pests suggest that the toxicity and side effects benzalkonium. Introduction: Colorless or yellowish powder or gummy amber solid, if pre ent and easy to do and. However they may be marketed if between 0.2-5 % -alkyldimethyl: Result: Irritating to skin topical! The biocide active substances review programme include drying the skin and that some people will drink.... Internally in active ingredient in many cleaning products made by household-name brands including.... Industry and medicine, where it is commonly detected in surface and wastewaters where it can kill up to %..., infant and young children active ingredient in many household disinfectants and are used to control.. Specific mixture severe eye irritant solutions of 10 % or more are toxic to humans, causing to.

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